Pharmaceutical & Biotechnology

Water for pharmaceutical use (EUP) is the most widely used ingredient in the manufacture of drugs, the main component in cleaning and disinfecting equipment; therefore, pharmaceutical facilities for the production, storage, distribution of water for pharmaceutical use and pure steam are essential elements. WTT, using its know-how, is committed to providing facilities in accordance with the customer’s request and guarantees to take great care to avoid any chemical and especially bacterial contamination.

These waters for pharmaceutical use exist in two different bulk forms. Purified Bulk Water (EPV) and Water for Injections Bulk (EPPIV) are described in detail in all pharmacopoeias, including the American, European, Japanese and Chinese Pharmacopoeias. Pure condensed vapor is considered EPPIV.For the production of liquid, solid, injectable or biological drugs, the pharmaceutical industry uses these two qualities of water: EPV and EPPIV. Different technologies for the purification of drinking water (good for human consumption) are available to produce these two qualities of water for pharmaceutical use. WTT takes a lot of care in pre-processing to be able to use the best production technology. The performances are linked to the quality of drinking water supplied or made drinkable and to the quality of the water for pharmaceutical use requested, to the investment cost, to the operating cost, to its reliability, to its robustness, its sustainability and the elimination or reduction of risks associated with the chosen technology.WTT as a specialist meets all these criteria and with its team of experts, carries out the engineering, design, construction and installation of production and distribution facilities for water for pharmaceutical use. Of course WTT also performs commissioning, qualifications (design qualification, installation qualification and operational qualification) and maintenance. WTT installations for the production and distribution of water for pharmaceutical use (purified water in bulk (EPV), water for bulk preparations (EPPIV), pure steam (VP) are robust and provide the continuous performance required. water for pharmaceutical use and pure steam comply with current pharmacopoeias and good manufacturing practices (GMP).
Distribution system
WTT is putting in place the means to make water for pharmaceutical use available at points of use (POU), while maintaining its quality. WTT includes tanks, pumps, heat exchangers, piping, valves and accessories, radiation generators , UV, ozone generators (by electrolysis). WTT also installs the management and monitoring elements (sensors and regulators). WTT connects the fluids (drinking water, ozone, nitrogen, compressed air, steam, glycol water, electricity) necessary for the proper functioning of the installation.WTT takes care that all the elements in contact with water for pharmaceutical use are of high quality and homogeneous roughness: tanks, pipes, etc. Any lack of homogeneity will be justified by WTT. The choice of surface quality is linked to the technologies implemented in terms of disinfection and sterilization. WTT sizes the distribution loop so that the circulation regime of water for pharmaceutical use is turbulent. In this case, the Reynolds number must always be greater than 4000. Indeed, the laminar regime (speed equal to zero at the walls) increases the risks of adhesion of microorganisms in the event of contamination (biofilm). WTT makes the loop without a retention zone, without a dead arm, with the instrumentation and accessories mounted on a clamp (with an equivalent surface finish).